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Tuberculosis reinfection in a pregnant cystic fibrosis patient

Asween Marco1, Maria Theresa Montales2, Penchala Mittadodla2

  • 1Arkansas Department of Health, USA; University of Arkansas at Little Rock, USA.

Respiratory Medicine Case Reports
|January 9, 2016
PubMed

Cystic Fibrosis (CF) is a multisystem disease predominantly affecting the airways and predisposing patients to recurrent infections with various multidrug resistant organisms. Mycobacterium tuberculosis (MTB) infection is rarely seen, but considered a potential pathogen in CF patients. We report a 26 year old pregnant CF patient on Ivacaftor who was admitted with symptoms suggestive of tuberculosis. Three years prior to the current admission, she had completed four drug anti- MTB therapy for pulmonary tuberculosis and was considered cured as her sputum cultures after six months of treatment were negative. Genotype analysis revealed the current MTB strain to be different from the strain causing the previous infection. After receiving first line anti-tuberculous regimen for nine months, the patient's condition markedly improved culminating in an uneventful pregnancy and delivery. To our knowledge, this is the only reported case of reinfection tuberculosis in a CF patient.

Keywords:
AFBCystic fibrosisGeneXpert MTB/RIF assayGenotypingMycobacterium tuberculosis

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