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Bone Formation by Endochondral Ossification01:24

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Bone formation, or ossification, begins around the sixth to seventh week of embryonic development. Most bones develop from a cartilaginous template through the process of endochondral ossification. Cartilage formation begins when clusters of mesenchymal cells differentiate into chondrocytes. These chondrocytes proliferate rapidly and secrete an extracellular matrix that becomes encased in a membrane called the perichondrium. The resulting cartilage model provides a template that resembles the...
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Intramembranous ossification is one of the two processes involved in the development of bones within an embryo. The flat bones of the face, most of the cranial bones, and the clavicles are formed via this process. During intramembranous ossification, the bones develop directly from sheets of undifferentiated mesenchymal connective tissue.
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Chondrocytes form a temporary cartilaginous model by dividing and secreting a thick gel-like extracellular matrix. Once the chondrocytes undergo programmed cell death, osteoblasts enter the site of the cartilaginous model. The process of replacing the temporary cartilaginous model with bone in an ordered manner is called endochondral ossification. In endochondral ossification, not all of the cartilage is replaced by bone tissue. Some cartilage that performs a protective and supportive function...
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The oral cavity, or the mouth, is a complex structure in humans that plays a vital role in our day-to-day lives. Its role is not only in chewing and swallowing food; it also plays a role in speech and facial expressions.
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Palatal Osseous Choristoma.

Ryo Sasaki1, Tomoko Yamamoto, Tomohiro Ando

  • 1*Department of Oral and Maxillofacial Surgery, Tokyo Women's Medical University, School of Medicine, Tokyo, Japan †Clinic of Craniomaxillofacial and Oral Surgery, Medical University of Innsbruck, Innsbruck, Austria ‡Department of Surgical Pathology, Tokyo Women's Medical University, School of Medicine, Tokyo, Japan.

The Journal of Craniofacial Surgery
|January 9, 2016
PubMed
Summary
This summary is machine-generated.

Osseous choristoma, a rare benign oral tumor, presents as bone in soft tissue. This case report details a palate osseous choristoma, successfully treated with surgical excision.

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Area of Science:

  • Oral Pathology
  • Histopathology
  • Surgical Oncology

Background:

  • Osseous choristoma is a rare benign tumor characterized by the presence of normal bone tissue in an abnormal soft tissue location.
  • These lesions are uncommon in the oral cavity, necessitating detailed case reporting for better understanding.

Observation:

  • A 37-year-old male presented with a pedunculated, hard, healthy-colored mass measuring approximately 6x5 mm on the median palate.
  • The mass was asymptomatic and discovered incidentally.

Findings:

  • Surgical excision of the palatal mass was performed.
  • Histopathological examination revealed a dense lamellar bone nodule within fibrous connective tissue, beneath the squamous epithelium.
  • Immunohistochemical analysis was negative for S-100 protein, cytokeratin, and epithelial membrane antigens, confirming the diagnosis.

Implications:

  • This case contributes to the literature on rare oral soft tissue tumors.
  • Accurate diagnosis through histopathology and immunohistochemistry is crucial for differentiating osseous choristoma from other oral lesions.
  • Surgical removal is an effective treatment for symptomatic or concerning osseous choristomas.