Related Experiment Video
Updated: Mar 27, 2026
12:21
A Versatile Automated Platform for Micro-scale Cell Stimulation Experiments
Published on: August 6, 2013
11.1K
Nanoscale bio-platforms for living cell interrogation: current status and future perspectives
Lingqian Chang1, Jiaming Hu, Feng Chen
1NSF Nanoscale Science and Engineering Center (NSEC), The Ohio State University, Columbus, OH 43212, USA. lee.31@osu.edu.
Nanoscale
|January 9, 2016
Summary
Nanoscale platforms offer advanced tools for studying living cells at the single-cell level. This review details innovations in nano-biosensors, nanodevices, high-throughput systems, and imaging for cell analysis and clinical applications.
Area of Science:
- Cell Biology
- Nanotechnology
- Biomedical Engineering
Background:
- Living cells dynamically respond to internal and external signals.
- Understanding single-cell functions (proliferation, apoptosis, differentiation) is crucial.
- Modern techniques enable quantitative analysis of RNA/protein expression at the single-cell level.
Purpose of the Study:
- To review background and technical innovations of nanoscale platforms for living cell interrogation.
- To categorize and detail current nanoscale technologies for cell analysis.
- To discuss future perspectives for improving techniques for clinical use.
Main Methods:
- Review of currently reported nanoscale platforms for living cell interrogation.
- Detailed documentation of technologies in four categories: nano-biosensors, nanodevices for marker delivery, high-throughput platforms, and microscopic imaging.
- Discussion of system improvements and limitations.
Main Results:
- Nano-biosensors enable label-free detection of living cells.
- Nanodevices facilitate intracellular marker delivery for cell probing.
- High-throughput platforms and advanced microscopic imaging aid in cell/tissue tracking.
- Progress in nanoscale platforms enhances spatial and temporal resolution in cell analysis.
Conclusions:
- Nanoscale platforms are revolutionizing living cell analysis with high resolution.
- These technologies offer significant potential for clinical applications.
- Further system improvements are needed to overcome current limitations for widespread clinical use.
