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Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
Published on: August 30, 2018
Managing drug-resistant organisms in acute care
Kimberly L Nealy1, Delilah J McCarty, J Andrew Woods
1Kimberly L. Nealy is an assistant professor of Pharmacy Practice at Wingate University School of Pharmacy, Wingate, N.C. Delilah J. McCarty is an assistant professor of Pharmacy Practice at Wingate University School of Pharmacy, Wingate, N.C. J. Andrew Woods is an assistant professor of Pharmacy at Wingate University School of Pharmacy, Wingate, N.C.
This article discusses managing infections from drug-resistant organisms in hospitals. It emphasizes accurate organism identification and judicious antibiotic use to combat antimicrobial resistance.
Area of Science:
- Infectious Diseases
- Clinical Microbiology
- Pharmacology
Background:
- Antimicrobial resistance (AMR) poses a significant threat in acute care settings.
- Drug-resistant organisms complicate treatment and increase patient morbidity and mortality.
- The emergence of multidrug-resistant pathogens necessitates updated therapeutic strategies.
Purpose of the Study:
- To outline therapeutic considerations for treating infections caused by drug-resistant organisms.
- To guide practitioners in managing antimicrobial resistance in acute care.
- To highlight the importance of diagnostic accuracy and antibiotic stewardship.
Main Methods:
- Review of current literature on drug-resistant infections.
- Analysis of therapeutic guidelines and clinical case studies.
- Discussion of diagnostic approaches for pathogen identification.
Main Results:
- Effective management hinges on precise identification of the causative organism.
- Judicious antibiotic selection and administration are critical to treatment success.
- Implementing antimicrobial stewardship programs is essential for controlling resistance.
Conclusions:
- Therapeutic strategies must adapt to the evolving landscape of drug-resistant pathogens.
- Accurate diagnostics and appropriate antibiotic use are cornerstones of infection control.
- Reducing the spread of antimicrobial resistance requires a multi-faceted approach in acute care.
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