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Effect of antemortem and postmortem factors on [3H]MK-801 binding in the human brain: transient elevation during
J Kornhuber1, F Mack-Burkhardt, C Konradi
1Department of Psychiatry, University of Würzburg, F.R.G.
Life Sciences
|January 1, 1989
Abstract:
The effect of a number of antemortem and postmortem factors on [3H]MK-801 binding was investigated under equilibrium conditions in the frontal cortex of human brains of 38 controls. Binding values transiently increased during the early postnatal period reaching a maximum at the age of about 2 years. After age 10 years [3H]MK-801 binding sites disappeared at 5.7% per decade. The storage time of brain tissue had a reducing effect on these binding sites. There was no effect of gender, brain weight or postmortem time interval and the binding sites were bilaterally symmetrically distributed in the frontal cortex.