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Related Experiment Videos

Does exercise training alter myocardial creatine kinase MB isoenzyme content?

T D Miller1, P J Rogers, B A Bauer

  • 1Division of Cardiovascular Diseases and Internal Medicine, Mayo Clinic, Rochester, MN 55905.

Medicine and Science in Sports and Exercise
|August 1, 1989
PubMed
Summary

Exercise training does not cause significant damage to the heart muscle. Studies show that the heart muscle (myocardium) does not undergo the same regenerative process as skeletal muscle after exercise.

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Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference·2007

Area of Science:

  • Exercise physiology
  • Cardiovascular research
  • Biochemistry

Background:

  • Skeletal muscle adaptation to endurance training involves regeneration.
  • This regeneration is linked to increased creatine kinase MB (CK-MB) isoenzyme.
  • It is unknown if the heart muscle (myocardium) undergoes similar changes.

Purpose of the Study:

  • To investigate if chronic exercise training induces degenerative-regenerative changes in the myocardium.
  • To compare CK-MB levels in the myocardium of trained versus untrained animals.

Main Methods:

  • 12-week exercise training or cage confinement in mongrel dogs.
  • Analysis of left and right ventricular myocardium for total CK activity and CK-MB isoenzyme.
  • Comparison of CK-MB percentages between trained and control groups.

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Main Results:

  • Slight, non-significant increases in myocardial CK-MB percentages in trained dogs compared to controls.
  • Left ventricle: 4.6% (trained) vs 3.3% (control).
  • Right ventricle: 4.0% (trained) vs 3.0% (control).

Conclusions:

  • Chronic exercise training does not induce significant degenerative changes in the myocardium.
  • The heart muscle does not appear to undergo the same exercise-induced regenerative process as skeletal muscle.