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XPC intron11 C/A polymorphism as a risk factor for prostate cancer.
Yoshihiro Yoshino1, Shouhei Takeuchi1, Takahiko Katoh2
1Department of Public Health, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki, 889-1692, Japan.
Environmental Health and Preventive Medicine
|January 10, 2016
Summary
The Xeroderma pigmentosum complementation group C (XPC) intron11 C/A polymorphism is linked to a higher prostate cancer risk. Among non-smokers, the XPC A/A genotype showed a significantly increased prevalence in prostate cancer patients.
Area of Science:
- Genetics
- Oncology
- Molecular Biology
Background:
- DNA repair genes are crucial for preventing cancer by addressing DNA damage.
- Xeroderma pigmentosum complementation group C (XPC) protein is vital for recognizing DNA damage in nucleotide excision repair.
- The association between the XPC intron11 C/A polymorphism and cancer risk, particularly prostate cancer, requires further investigation.
Purpose of the Study:
- To evaluate the association between the XPC intron11 C/A polymorphism and the risk of developing prostate cancer.
- To investigate if smoking status modifies the relationship between the XPC intron11 C/A polymorphism and prostate cancer risk.
Main Methods:
- A hospital-based cohort study included 152 prostate cancer patients and 142 male controls.
- XPC intron11 C/A genotypes were determined using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method.
- Participant data on medical history, occupation, and smoking habits were collected via questionnaires.
Main Results:
- Logistic regression analysis indicated that individuals with XPC intron11 A/A and C/A genotypes had a significantly higher risk of prostate cancer compared to the C/C genotype (OR = 2.03, 95% CI 1.03-3.98 and OR = 1.91, 95% CI 1.13-3.24, respectively).
- Among non-smokers, the A/A genotype was significantly more prevalent in prostate cancer patients than in controls (OR = 7.7, 95% CI 1.38-42.88).
Conclusions:
- The XPC intron11 C/A polymorphism is associated with an increased risk of prostate cancer.
- The A/A genotype of the XPC intron11 C/A polymorphism is a significant risk factor for prostate cancer, especially in non-smokers.
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