Related Experiment Video
Updated: Aug 11, 2026

Linear Amplification Mediated PCR – Localization of Genetic Elements and Characterization of Unknown Flanking DNA
Published on: June 25, 2014
The mutagenic and carcinogenic effects of gene transfer
1Program in Cancer Biology, Stanford University School of Medicine, CA 94305.
Abstract:
Transfection can induce chromosome rearrangements, other types of mutations and epigenetic changes in recipient cells. Transfected DNA is degraded, mutated and recombined much more frequently than is endogenous chromatin. There is evidence that foreign DNA can interact with homologous cellular sequences, thus increasing the chances that these sequences will undergo mutation. In addition, there are several steps in the process of transfection during which a subpopulation of cells could be selected.
More Related Videos
Related Concept Videos
What is Genetic Engineering?
In-vitro Mutagenesis
Gene Therapy
Transgenic Plants
The first-ever transgenic plant was a tobacco plant developed in 1983 that showed resistance against the tobacco mosaic virus. Since then, many transgenic plants have been developed and commercialized for improving the agricultural, ornamental, and horticultural value of a crop plant. Transgenic...
Gene Therapy
Mutagenicity and Carcinogenicity

