Related Experiment Video
Updated: Mar 27, 2026
12:48
Isolation and Analysis of Brain-sequestered Leukocytes from Plasmodium berghei ANKA-infected Mice
Published on: January 2, 2013
13.3K
Cerebral malaria--clinical manifestations and pathogenesis
Rachna Hora1, Payal Kapoor2, Kirandeep Kaur Thind2
1Department of Molecular Biology and Biochemistry, Guru Nanak Dev University, Amritsar, 143005, India. rachnahora@gmail.com.
Metabolic Brain Disease
|January 10, 2016
Summary
Cerebral malaria (CM), a common CNS disease in tropics, causes mortality and neurological deficits. This review details CM
Area of Science:
- Neurology
- Infectious Diseases
- Tropical Medicine
Background:
- Cerebral malaria (CM) is a severe complication of Plasmodium falciparum infection, prevalent in tropical regions.
- CM poses a significant global health challenge, leading to high mortality and substantial economic impact.
- Survivors often experience long-term neurological impairments, particularly in pediatric cases.
Purpose of the Study:
- To review the diverse clinical manifestations of CM in both children and adults.
- To elucidate the underlying molecular mechanisms contributing to CM pathogenesis.
- To explore potential therapeutic strategies for improving outcomes in CM patients.
Main Methods:
- Comprehensive literature review of studies on cerebral malaria.
- Analysis of molecular pathways involved in CM pathogenesis.
- Examination of data from experimental mouse models of malaria.
Main Results:
- Detailed summary of CM symptoms and clinical presentations.
- Explanation of the roles of parasite and host factors in disease progression, including BBB disruption and neuroinflammation.
- Insights into the molecular basis of neurological sequelae from experimental models.
Conclusions:
- Understanding the molecular pathogenesis of CM is crucial for developing effective treatments.
- Host-parasite interactions significantly influence CM outcomes.
- Further research, informed by experimental models, can guide therapeutic interventions to improve prognosis.
More Related Videos
09:04In Vivo Tracking of Edema Development and Microvascular Pathology in a Model of Experimental Cerebral Malaria Using Magnetic Resonance Imaging
Published on: June 8, 2017
7.0K
07:27A Simple Protocol for Platelet-mediated Clumping of Plasmodium falciparum-infected Erythrocytes in a Resource Poor Setting
Published on: May 16, 2013
19.2K
Related Concept Videos
00:58Symbiosis
38.4K
Symbiotic relationships are long-term, close interactions between individuals of different species that affect the distribution and abundance of those species. When a relationship is beneficial to both species, this is called mutualism. When the relationship is beneficial to one species but neither beneficial nor harmful to the other species, this is called commensalism. When one organism is harmed to benefit another, the relationship is known as parasitism. These types of relationships often...
38.4K
01:18Viral Meningitis
44
Viral meningitis is the most common form of meningitis and is often referred to as aseptic meningitis to indicate the absence of bacterial involvement. It is generally milder than bacterial meningitis, with symptoms including fever, headache, stiff neck, drowsiness, nausea, photophobia, and vomiting. Rarely, more severe manifestations or death may occur. Common causative agents include enteroviruses, particularly coxsackie A and B viruses and echoviruses, all members of the Enterovirus genus...
44
01:25Arboviral Encephalitis
22
Arboviral encephalitis refers to brain inflammation caused by arthropod-borne viruses, particularly those transmitted through mosquito vectors. Among these, West Nile virus (WNV), a member of the Flaviviridae family, is a significant public health concern. WNV is an enveloped, positive-sense, single-stranded RNA virus. Human infection typically begins when an infected mosquito introduces the virus into the dermis during feeding. The primary transmission cycle involves birds as amplifying hosts...
22
01:27Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders
2.4K
Schizophrenia is a neurodevelopmental disorder whose origins are rooted in complex genetic components. Despite our burgeoning understanding, the pathophysiology of this disorder remains incompletely deciphered.
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
2.4K
01:27Diversity of Protists II
2.2K
Alveolates are a group of organisms recognized by the presence of alveoli, which are cytoplasmic sacs located beneath the cell membrane. While their function remains uncertain, alveoli may help regulate water balance by controlling how much water enters and leaves the cell. In dinoflagellates, these structures may serve as armor plates. There are three major types of alveolates: ciliates, which move using cilia; dinoflagellates, which use flagella for movement; and apicomplexans, which are...
2.2K