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Establishment of an Ex Vivo Lung Perfusion Rat Model for Translational Insights in Lung Transplantation
Published on: September 29, 2023
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Ex vivo lung graft perfusion.
Raphaël Briot1, Stéphane Gennai1, Maxime Maignan1
1Pôle urgences médecine aiguë, CHU de Grenoble, laboratoire TIMC, équipe PRETA UMR CNRS 5525, université Joseph-Fourier, 38043 Grenoble cedex 09, France.
Anaesthesia, Critical Care & Pain Medicine
|January 10, 2016
Summary
Ex vivo lung perfusion (EVLP) evaluates donor lungs outside the body, potentially rescuing grafts initially rejected for transplantation. This technique shows promising results, improving lung graft utilization and understanding of injury.
Area of Science:
- Thoracic surgery and transplantation
- Pulmonary medicine
- Regenerative medicine
Background:
- Lung transplantation faces donor lung scarcity, with many grafts rejected due to suboptimal criteria.
- Ischemia-reperfusion injury is a significant challenge in preserving lung grafts.
- Ex vivo lung perfusion (EVLP) offers a method to assess and potentially improve rejected lung grafts.
Purpose of the Study:
- To provide an updated review of ex vivo lung perfusion (EVLP) techniques for lung transplantation.
- To summarize current clinical trials and developments in EVLP technology.
- To explore the role of EVLP in evaluating and potentially rescuing lung grafts.
Main Methods:
- Review of current literature and ongoing clinical trials on ex vivo lung perfusion (EVLP).
- Description of EVLP procedures, emphasizing progressive perfusion and ventilation to prevent edema.
- Evaluation of lung grafts based on gasometric (PaO2/FiO2) and rheological (pulmonary arterial resistance) criteria.
Main Results:
- Published patient series demonstrate promising outcomes for transplants using EVLP-evaluated lungs.
- EVLP aids in understanding the pathophysiology and treatment of ischemia-reperfusion injuries.
- The technique is crucial for utilizing organs from non-heart-beating donors.
Conclusions:
- Ex vivo lung perfusion (EVLP) is a valuable tool for assessing and potentially improving lung graft viability.
- EVLP can expand the donor pool and improve lung transplantation success rates.
- Advancements in semi-automated systems are expected to increase the clinical adoption of EVLP.
