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Related Experiment Video

Updated: Mar 27, 2026

A Chronic Sleep Fragmentation Model using Vibrating Orbital Rotor to Induce Cognitive Deficit and Anxiety-Like Behavior in Young Wild-Type Mice

A Chronic Sleep Fragmentation Model using Vibrating Orbital Rotor to Induce Cognitive Deficit and Anxiety-Like Behavior in Young Wild-Type Mice

Published on: September 22, 2020

Chronical sleep interruption-induced cognitive decline assessed by a metabolomics method.

Li Feng¹, Hong-wei Wu¹, Guang-qing Song¹

¹Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100093, China.

Behavioural Brain Research

|January 10, 2016

Summary

Chronic sleep interruption impairs cognitive function and alters metabolic pathways in mice. This study reveals potential biomarkers and mechanisms underlying sleep deprivation-induced cognitive decline.

Keywords:

Chronical sleep interruption Learning and memory Mice New objects preference task Serum metabolic profiling Temporal order judgment task

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Noninvasive, High-throughput Determination of Sleep Duration in Rodents

Noninvasive, High-throughput Determination of Sleep Duration in Rodents

Published on: April 18, 2018

Area of Science:

Neuroscience
Metabolomics
Sleep Research

Background:

Sleep is crucial for cognitive functions like learning and memory.
Sleep deprivation and insomnia are linked to cognitive decline, but mechanisms are unclear.
Chronic Sleep Interruption (CSI) is a model to study sleep disorder effects.

Purpose of the Study:

To investigate the impact of CSI on cognitive function in a mouse model.
To explore the underlying pathophysiological mechanisms, including oxidative stress and metabolic changes.
To identify potential serum biomarkers associated with CSI-induced cognitive impairment.

Main Methods:

Induced CSI in mice for 14 days.
Assessed cognitive function using New Objects Preference (NOP) and Temporal Order Judgment (TOJ) tasks.
Analyzed serum corticosterone, brain oxidative stress markers (MDA, SOD, CAT), and performed LC-MS based serum metabolic profiling.

Main Results:

CSI significantly impaired cognitive function in mice.
CSI mice exhibited increased corticosterone and MDA, with decreased SOD and CAT levels.
Thirteen potential serum biomarkers were identified, implicating purine, retinoid, lipid, and amino acid metabolism.

Conclusions:

CSI leads to notable cognitive decline in mice.
Oxidative stress and disturbed metabolic pathways contribute to CSI-induced cognitive impairment.
Identified biomarkers and pathways offer insights into sleep disorder-related cognitive dysfunction.