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Probiotic Compared with Standard Milk for High-caries Children: A Cluster Randomized Trial

G Rodríguez1, B Ruiz1, S Faleiros1

  • 1Department of Restorative Dentistry, University of Chile, Santiago, Chile.

Journal of Dental Research
|January 10, 2016
PubMed

Insights

Regularly drinking milk with Lactobacillus rhamnosus SP1 may reduce cavities in young children. This probiotic intervention showed a significant decrease in new cavities compared to standard milk over 10 months.

Area of Science:

  • Oral Health
  • Microbiology
  • Pediatric Dentistry

Background:

  • Dental caries is a prevalent issue in preschool children.
  • Early intervention strategies are crucial for preventing caries progression.
  • Probiotics, specifically Lactobacillus species, show potential in modulating oral microbiota.

Purpose of the Study:

  • To evaluate the efficacy of milk supplemented with Lactobacillus rhamnosus SP1 in preventing dental caries increment in preschool children.
  • To compare caries development between children consuming probiotic-supplemented milk and standard milk over a 10-month period.

Main Methods:

  • A triple-blind, placebo-controlled randomized trial was conducted with 261 preschool children (aged 2-3 years).
  • Participants were assigned to receive either 150 mL of milk with Lactobacillus rhamnosus SP1 (10(7) CFU/mL) or standard milk on weekdays for 10 months.
  • Caries increment was assessed using the International Caries Detection and Assessment System (ICDAS).

Main Results:

  • The probiotic group had a lower caries prevalence (54.4%) compared to the control group (65.8%) after 10 months.
  • Significantly fewer children in the probiotic group developed cavitated lesions (9.7%) versus the control group (24.3%).
  • The odds ratio for caries increment favored the probiotic group (0.35, P < 0.05), with fewer new lesions per child (1.13 vs. 1.75, P < 0.05).

Conclusions:

  • Regular, long-term intake of probiotic-supplemented milk can significantly reduce caries development in high-caries risk preschool children.
  • Lactobacillus rhamnosus SP1 in milk demonstrates a protective effect against the increment of dental caries.
  • Probiotic milk intervention represents a promising strategy for pediatric caries prevention.

Keywords:
Lactobacillus rhamnosus SP1bacteriotherapycaries preventionearly childhood cariespreschool childrensupplemented milk

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