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Updated: Mar 27, 2026
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Assessing Pupil-linked Changes in Locus Coeruleus-mediated Arousal Elicited by Trigeminal Stimulation
Published on: November 26, 2019
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More than Meets the Eye: the Relationship between Pupil Size and Locus Coeruleus Activity
Vincent D Costa1, Peter H Rudebeck2
1National Institute of Mental Health, Bethesda, MD 20814, USA.
Neuron
|January 10, 2016
Abstract:
Using both direct neural recordings and electrical microstimulation, Joshi et al. (2016) show that locus coeruleus (LC) activity closely matches moment-to-moment changes in pupil size. But what causes these two measures to be related is not straightforward.
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