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Related Experiment Videos

Multicentric familial squamous odontogenic tumor.

A S Leider1, L A Jonker, H E Cook

  • 1Department of Diagnostic Sciences, University of the Pacific School of Dentistry, San Francisco, Calif.

Oral Surgery, Oral Medicine, and Oral Pathology
|August 1, 1989
PubMed
Summary

Multicentric squamous odontogenic tumors in siblings suggest a possible familial link, challenging the notion of this rare odontogenic neoplasm being solely sporadic. This finding may indicate a reactive hyperplasia or hamartoma rather than a true neoplasm.

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Area of Science:

  • Oral pathology
  • Odontogenic neoplasms
  • Genetics in dentistry

Background:

  • Squamous odontogenic tumor (SOT) is a rare benign odontogenic neoplasm.
  • Previous literature has not suggested a familial predisposition for SOT.
  • Multicentric occurrence of SOT is uncommon.

Observation:

  • Presents three cases of multicentric squamous odontogenic tumor in black siblings.
  • One of the presented cases was previously reported.
  • Reviews literature, identifying 5 of 26 previously recorded cases with multiple sites.

Findings:

  • The familial occurrence in siblings challenges the typical understanding of SOT.
  • Suggests multicentric SOT might represent reactive hyperplasia or hamartoma of residual odontogenic epithelium.

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  • Highlights the potential genetic or hereditary component in certain SOT presentations.

    • Implications:

    • Re-evaluation of the classification and etiology of multicentric SOT is warranted.
    • Consideration of genetic factors in the differential diagnosis of SOT, especially in familial cases.
    • Informs clinical management and prognosis for patients with multicentric SOT.