25 by 25: Achieving Global Reduction in Cardiovascular Mortality

Sagar Dugani1,2, Thomas A Gaziano3

  • 1Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, 02115, USA. sagar.dugani@utoronto.ca.

Insights

Non-communicable diseases (NCDs) cause most global deaths. The UN aims to reduce major NCDs by 25% by 2025, focusing on cardiovascular disease (CVD) and lifestyle factors.

Area of Science:

  • Public Health
  • Epidemiology
  • Global Health

Background:

  • Non-communicable diseases (NCDs) like cardiovascular disease (CVD), chronic respiratory disease, diabetes, and cancer cause over 60% of global deaths.
  • Cardiovascular disease is the leading cause of death worldwide, accounting for half of all NCD deaths and up to 60% in some regions.

Purpose of the Study:

  • To outline global strategies and targets for reducing NCD mortality by 2025.
  • To highlight the focus on cardiovascular disease as a primary target for intervention.

Main Methods:

  • The United Nations established a target to reduce major NCDs by 25% by 2025.
  • The World Health Organization (WHO) set specific targets for conditions and risk factors, including lifestyle (physical activity, salt intake, tobacco) and established conditions (obesity, hypertension, diabetes).

Main Results:

  • Focus on lifestyle risk factors and established conditions is central to achieving NCD reduction goals.
  • Encouragement of health system efforts to improve medical treatment for high-risk individuals.

Conclusions:

  • International organizations are promoting efforts to achieve NCD reduction targets.
  • A multi-faceted approach involving lifestyle changes, condition management, and healthcare system improvements is crucial for combating the NCD epidemic.

Related Concept Videos

Atherosclerosis III: Management01:26

Atherosclerosis III: Management

Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
578
Coronary Artery Disease IV: Preventive Measures01:26

Coronary Artery Disease IV: Preventive Measures

Effective preventive measures for coronary artery disease (CAD) focus on controlling modifiable risk factors, including cholesterol abnormalities and lifestyle changes.Cholesterol ManagementFirst, the Mediterranean diet and the American Heart Association advocate for maintaining low-density lipoprotein (LDL) cholesterol levels below 100 mg/dL, with a more stringent recommendation of below 70 mg/dL for individuals at high risk. LDL cholesterol, often termed "bad cholesterol," can lead to the...
839
Methods Of Healthcare Delivery System01:26

Methods Of Healthcare Delivery System

At the different levels of the healthcare system, we see varying methods of healthcare used. These methods include managed care systems, case management, and primary healthcare.
Managed Care System:
The managed care system is designed to control the cost while maintaining the quality of care. The patient's care from admission to discharge is planned by the primary care provider or the case manager, also known as the gatekeeper. In a managed care system, the number of care providers is...
4.2K
Hypertension IV: Drug Therapy and Lifestyle Modifications01:28

Hypertension IV: Drug Therapy and Lifestyle Modifications

Multiple classes of antihypertensive medications are employed in treating hypertension. The most commonly recommended first-line treatments include:Thiazide Diuretics, such as chlorthalidone, increase sodium and water excretion from the body, reducing blood volume and blood pressure.Angiotensin-converting enzyme inhibitors, like lisinopril, block the conversion of angiotensin I to II, a potent vasoconstrictor lowering blood pressure.Angiotensin II Receptor Blockers (ARBs) prevent angiotensin II...
831
Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
1.6K
Regulation of the Cardiovascular System01:27

Regulation of the Cardiovascular System

The regulation of the cardiovascular system allows the body to adapt to various demands and maintain homeostasis.
The regulation of the cardiovascular system involves the autonomic nervous system (ANS), baroreceptors, and chemoreceptors, ensuring that heart rate and blood pressure are appropriately modulated in response to varying physiological demands.
The ANS comprises two main divisions: the sympathetic and parasympathetic nervous systems. The sympathetic nervous system enhances...
5.1K