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Related Concept Videos

Adult Stem Cells01:33

Adult Stem Cells

34.3K
Stem cells are undifferentiated cells that divide and produce more stem cells or progenitor cells that differentiate into mature, specialized cell types. All the cells in the body are generated from stem cells in the early embryo, but small populations of stem cells are also present in many adult tissues including the bone marrow, brain, skin, and gut. These adult stem cells typically produce the various cell types found in that tissue—to replace cells that are damaged or to continuously...
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Renewal of Intestinal Stem Cells01:23

Renewal of Intestinal Stem Cells

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The intestinal epithelial lining rapidly renews every 4 to 5 days. The renewal is facilitated by intestinal stem cells (ISCs) located at the base of the crypt– a gland located at the bottom of each villus. ISCs divide asymmetrically to form new stem cells and progenitor daughter cells. The daughter cells are called transit-amplifying (TA) cells which move upwards along the crypt and either differentiate into absorptive cells– the enterocytes or secretory cells– including the...
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Hormones Secreted by the Stomach01:25

Hormones Secreted by the Stomach

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Enteroendocrine cells, accounting for only 1% of stomach epithelial cells, play a significant role in digestion and are classified by their digestive hormone secretions.
Each of these hormones secreted by different enteroendocrine cells plays a unique role in digestion. Here are a few examples:
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Tissue Renewal without Stem Cells01:23

Tissue Renewal without Stem Cells

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After cellular or tissue damage, the resident stem cells present in the human body can locally repair and regenerate the damaged tissue or organ. However, even though some tissues do not have stem cells, they can repair and regenerate with the help of pre-existing cells. For example, beta cells of the pancreas and hepatocytes of the liver can divide to renew and regenerate the tissue. Here, both cell division and cell death are well regulated by homeostasis.
However, failure of such a system...
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Embryonic Stem Cells00:58

Embryonic Stem Cells

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Embryonic stem (ES) cells are undifferentiated pluripotent cells, meaning they can produce any cell type in the body. This gives them tremendous potential in science and medicine since they can generate specific cell types for use in research or to replace body cells lost due to damage or disease.
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Embryonic Stem Cells00:57

Embryonic Stem Cells

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Embryonic stem (ES) cells were first discovered in mice in 1981 by Martin Evans. In 1998, James Thomson identified a method to isolate embryonic stem cells from humans. Human embryonic stem cells (hESCs) are obtained from 3-5 day old embryos that remain unused after an in vitro fertilization procedure.
ES cells are grown in a culture medium where they can divide indefinitely, creating ES cell lines. Under certain conditions, ES cells can differentiate, either spontaneously into a variety of...
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Related Experiment Video

Updated: Mar 27, 2026

A Novel Mammary Fat Pad Transplantation Technique to Visualize the Vessel Generation of Vascular Endothelial Stem Cells
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Lifting the Mist on Gastric Stem Cells.

Julia Varga1, Florian R Greten1

  • 1Institute for Tumor Biology and Experimental Therapy, Georg-Speyer-Haus, Paul-Ehrlich-Strasse 42-44, 60596 Frankfurt am Main, Germany.

Cell Stem Cell
|January 11, 2016
PubMed
Summary

Gastric stem cells are supported by a specialized niche of blood vessels and immune cells. This niche expands in diffuse-type gastric cancer, offering a potential target for new therapies.

Area of Science:

  • Gastroenterology
  • Immunology
  • Cancer Biology

Background:

  • Gastric stem cells are crucial for maintaining the stomach lining.
  • The microenvironment supporting stem cells is increasingly recognized as important in cancer.

Purpose of the Study:

  • To investigate the cellular components and structure of the niche supporting gastric stem cells.
  • To determine if this niche is altered in diffuse-type gastric cancer.
  • To explore the therapeutic potential of targeting this niche.

Main Methods:

  • Immunohistochemistry and single-cell RNA sequencing were used to identify cell types and their interactions.
  • Analysis of gastric tissue from healthy individuals and patients with diffuse-type gastric cancer.

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Combined Conditional Knockdown and Adapted Sphere Formation Assay to Study a Stemness-Associated Gene of Patient-derived Gastric Cancer Stem Cells
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Combined Conditional Knockdown and Adapted Sphere Formation Assay to Study a Stemness-Associated Gene of Patient-derived Gastric Cancer Stem Cells

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Author Spotlight: Generation of and Comparison Between Patient-Derived Gastric Organoids from Different Regions of the Stomach
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Author Spotlight: Generation of and Comparison Between Patient-Derived Gastric Organoids from Different Regions of the Stomach

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Combined Conditional Knockdown and Adapted Sphere Formation Assay to Study a Stemness-Associated Gene of Patient-derived Gastric Cancer Stem Cells
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Author Spotlight: Generation of and Comparison Between Patient-Derived Gastric Organoids from Different Regions of the Stomach
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Main Results:

  • Mist1-positive gastric stem cells are closely associated with CXCL12-positive endothelial cells.
  • Innate lymphoid cells producing WNT5A and expressing CXCR4 are integral components of this perivascular niche.
  • This specialized stem cell niche is significantly expanded in diffuse-type gastric cancer.

Conclusions:

  • The perivascular niche, comprising specific endothelial and innate lymphoid cells, is essential for supporting gastric stem cells.
  • The expansion of this niche in diffuse-type gastric cancer suggests its role in tumor progression.
  • Targeting this expanded niche presents a promising strategy for novel gastric cancer therapies.