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[Cytokines and osteoclastic action].

C Chenu1

  • 1Unité INSERM 234, Secteur Biochimie, Hôpital E.-Herriot, Lyon, France.

Pathologie-Biologie
|June 1, 1989
PubMed
Summary

Osteoclasts are key bone cells, but their origin, fate, and activation remain unclear. This review details growth factors influencing osteoclast formation and activation, crucial for bone resorption.

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Area of Science:

  • Cell Biology
  • Bone Biology
  • Endocrinology

Context:

  • Osteoclast biology is crucial for bone remodeling and resorption.
  • Despite advances, osteoclast origin, fate, and activation mechanisms require further elucidation.
  • Bone resorption involves progenitor formation, osteoclast generation, and activation, all regulated by systemic factors.

Purpose:

  • To review current knowledge on osteoclast biology.
  • To identify and index growth factors impacting osteoclast formation and activation.

Summary:

  • Osteoclast formation and activation are complex processes regulated by hormones and growth factors.
  • This review focuses on the significant role of growth factors in modulating osteoclast activity.
  • Key aspects covered include osteoclast progenitor development, osteoclast generation in bone, and activation at mineralized bone surfaces.

Impact:

  • Provides a comprehensive overview of osteoclast biology for researchers.
  • Highlights the critical role of growth factors in bone resorption.
  • Serves as a reference for understanding bone diseases and developing therapeutic strategies.

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