Related Experiment Video

Updated: Mar 27, 2026

Operational and Intervention Effects of Targeted Tuina in Lumbar Intervertebral Disc Degeneration Model Rabbits
06:03

Operational and Intervention Effects of Targeted Tuina in Lumbar Intervertebral Disc Degeneration Model Rabbits

Published on: July 21, 2023

1.1K

[RESEARCH PROGRESS OF microRNA IN INTERVERTEBRAL DISC DEGENERATION]

Xinhua Li, Jian Cui, Guixin Sun

    Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi = Zhongguo Xiufu Chongjian Waike Zazhi = Chinese Journal of Reparative and Reconstructive Surgery
    |January 12, 2016
    PubMed
    Abstract

    Insights

    MicroRNAs (miRNAs) are implicated in intervertebral disc degeneration by affecting cell apoptosis and proliferation. Further research into miRNAs offers new diagnostic and therapeutic strategies for this condition.

    Area of Science:

    • Biomedical Science
    • Molecular Biology
    • Regenerative Medicine

    Background:

    • Intervertebral disc degeneration (IVDD) is a prevalent condition.
    • The molecular mechanisms underlying IVDD are not fully elucidated.

    Purpose of the Study:

    • To analyze the relationship between microRNAs (miRNAs) and intervertebral disc degeneration (IVDD).
    • To explore the potential of miRNAs as diagnostic and therapeutic targets for IVDD.

    Main Methods:

    • Comprehensive literature review and analysis of studies on miRNAs and IVDD.

    Main Results:

    • MicroRNAs regulate gene expression, influencing apoptosis and proliferation in intervertebral disc cells.
    • MicroRNAs contribute to IVDD by increasing inflammatory mediators and proteases.

    Conclusions:

    • MicroRNAs are a significant research focus in IVDD.
    • Understanding miRNA roles in IVDD pathogenesis can lead to novel diagnostic and therapeutic approaches.

    More Related Videos

    Optical Sectioning and Visualization of the Intervertebral Disc from Embryonic Development to Degeneration06:22

    Optical Sectioning and Visualization of the Intervertebral Disc from Embryonic Development to Degeneration

    Published on: July 8, 2021

    2.7K
    A Proinflammatory, Degenerative Organ Culture Model to Simulate Early-Stage Intervertebral Disc Disease.05:46

    A Proinflammatory, Degenerative Organ Culture Model to Simulate Early-Stage Intervertebral Disc Disease.

    Published on: February 14, 2021

    4.3K

    Related Concept Videos

    MicroRNAs01:22

    MicroRNAs

    MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After...
    24.6K
    MicroRNAs01:22

    MicroRNAs

    MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
    4.3K