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Perturbations of Circulating miRNAs in Irritable Bowel Syndrome Detected Using a Multiplexed High-throughput Gene Expression Platform
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Advances in Exploring the Role of Micrornas in Inflammatory Bowel Disease

Cinzia Ciccacci1, Cristina Politi, Giuseppe Novelli

  • 1Department of Biomedicine and Prevention, Section of Genetics, School of Medicine, University of Rome "Tor Vergata", Rome, Italy.

Microrna (Shariqah, United Arab Emirates)
|January 12, 2016
PubMed

Insights

MicroRNAs are key regulators of gene expression increasingly recognized for their role in inflammatory bowel diseases (IBD) pathogenesis. This review explores their involvement in conditions like Crohn's Disease and Ulcerative Colitis.

Area of Science:

  • Gastroenterology and Immunology
  • Molecular Biology
  • Genetics

Background:

  • Inflammatory bowel diseases (IBD), including Crohn's Disease and Ulcerative Colitis, arise from complex interactions between genetic predisposition and environmental triggers.
  • The genetic landscape of IBD has expanded, with recent focus shifting towards non-coding RNA molecules.

Purpose of the Study:

  • To provide a comprehensive overview of the role of microRNAs in the pathogenesis of inflammatory bowel diseases.
  • To highlight microRNAs as emerging factors in IBD development and progression.

Main Methods:

  • Literature review synthesizing current research on microRNAs and IBD.
  • Analysis of microRNA function in gene regulation, cellular processes, and immune responses relevant to IBD.

Main Results:

  • MicroRNAs are small non-coding RNAs crucial for gene expression and regulation.
  • These molecules are implicated in cellular proliferation, differentiation, signal transduction, and both innate and adaptive immune responses.
  • Emerging evidence points to a significant role for microRNAs in the underlying mechanisms of IBD.

Conclusions:

  • MicroRNAs represent a promising area of research for understanding and potentially treating inflammatory bowel diseases.
  • Further investigation into microRNA pathways could unveil novel therapeutic targets for Crohn's Disease and Ulcerative Colitis.

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