Related Experiment Video
Updated: Mar 27, 2026
In Vivo Evaluation of the Mechanical and Viscoelastic Properties of the Rat Tongue
Published on: July 6, 2017
Tongue electrical impedance in amyotrophic lateral sclerosis modeled using the finite element method
Adam Pacheck1, Alex Mijailovic1, Sung Yim1
1Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
Objective:
Electrical impedance myography (EIM) of the tongue has demonstrated alterations in patients with amyotrophic lateral sclerosis (ALS) compared to normal subjects. Whether these differences are due to reduced tongue size or diseased-associated alterations in the electrical characteristics of intrinsic tongue muscles is uncertain.
Methods:
We employed computer simulations using the finite element method, inputting data from healthy and ALS mouse muscle, to help answer that question, comparing our modeled results to human data.
Results:
The models revealed that much of the electrical current flows superficially in the tongue and that tongue thickness only begins to have a major impact on the measured impedance when substantial atrophy is present. Modeled values paralleled the human tongue data.
Conclusions:
These findings suggest that the observed changes in tongue impedance in ALS are mainly due to alterations in the electrical properties of the tongue and are not a mere consequence of tongue volume loss.
Significance:
Further development of EIM for evaluation of bulbar dysfunction in ALS may provide useful information on drug efficacy and could serve as a biomarker in future clinical trials.
