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Updated: Mar 27, 2026

Measurement of Lifespan in Drosophila melanogaster
Published on: January 7, 2013
Quantifying risk over the life course - latency, age-related susceptibility, and other time-varying exposure metrics
Molin Wang1,2,3, Xiaomei Liao1,3, Francine Laden2,3,4
1Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, U.S.A.
Abstract:
Identification of the latency period and age-related susceptibility, if any, is an important aspect of assessing risks of environmental, nutritional, and occupational exposures. We consider estimation and inference for latency and age-related susceptibility in relative risk and excess risk models. We focus on likelihood-based methods for point and interval estimation of the latency period and age-related windows of susceptibility coupled with several commonly considered exposure metrics. The method is illustrated in a study of the timing of the effects of constituents of air pollution on mortality in the Nurses' Health Study. Copyright © 2016 John Wiley & Sons, Ltd.
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