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Formation of Ordered Biomolecular Structures by the Self-assembly of Short Peptides
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Sequence dependent proton conduction in self-assembled peptide nanostructures.

Jenny Lerner Yardeni1, Moran Amit2, Gonen Ashkenasy3

  • 1Department of Materials Engineering, Ben-Gurion University of the Negev, Beer Sheva, Israel. nurita@bgu.ac.il and Department of chemistry, Ben-Gurion University of the Negev, Beer Sheva, Israel.

Nanoscale
|January 12, 2016
PubMed
Summary
This summary is machine-generated.

Bio-inspired peptide nanostructures show promise as proton conducting materials. Aromatic amino acids enhance proton conduction in both dry and humid conditions, paving the way for advanced electrochemical devices.

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Area of Science:

  • Materials Science
  • Electrochemistry
  • Biomaterials

Background:

  • Advancements in electrochemistry technologies rely on novel proton conducting polymers.
  • Proton transport in proteins serves as inspiration for developing new organic proton conductors.

Purpose of the Study:

  • To explore self-assembling peptide nanostructures as alternatives to traditional proton conducting polymers.
  • To investigate the role of amino acid side chains in promoting proton conduction in peptide nanotubes.

Main Methods:

  • Design and synthesis of d,l α-cyclic peptide nanotubes.
  • Characterization of proton conductivity under varying humidity conditions.
  • Modification of peptide sequences to include aromatic and carboxylic acid side chains, and non-natural naphthyl groups.

Main Results:

  • Aromatic amino acids significantly enhance proton conduction in peptide nanotubes under both high and low humidity.
  • Long-range order in dehydrated peptide networks is crucial for conductivity, driven by aromatic side chains.
  • Proton donating carboxylic acid side chains improve conductivity in hydrated networks, even with reduced order.
  • A novel cyclic peptide with naphthyl side chains demonstrated superior dehydrated conductivity while maintaining high hydrated conductivity.

Conclusions:

  • Self-assembling peptide nanostructures offer a versatile and modular platform for proton conducting materials.
  • Bio-inspired design principles can lead to enhanced performance in organic proton conductors.
  • These peptide-based materials hold potential for applications in energy conversion, storage, and other proton transport devices.