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Updated: Sep 15, 2026

Early Viral Entry Assays for the Identification and Evaluation of Antiviral Compounds
Published on: October 29, 2015
Chloroquine and acid vesicle function
D J Krogstad1, P H Schlesinger, I Y Gluzman
1Department of Medicine, Washington University School of Medicine, St. Louis, MO.
Abstract:
These studies suggest that the site of chloroquine action against the malaria parasite is the acid intracellular vesicle system, and that the critical first step in chloroquine action is to raise parasite vesicle pH. Measurements of acid vesicle buffering capacity and of 3H-chloroquine accumulation suggest that the parasite has a chloroquine-concentrating mechanism in its acid vesicles, although the molecule(s) responsible for this concentration has not been identified. Chloroquine resistance in P. falciparum results from rapid efflux of chloroquine from the resistant parasite. This phenomenon alone is sufficient to account for chloroquine resistance.
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