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Rationale for anti-CD137 cancer immunotherapy
Amani Makkouk1, Cariad Chester2, Holbrook E Kohrt1
1Department of Medicine, Division of Oncology, Stanford University, Stanford, CA 94305 USA.
European Journal of Cancer (Oxford, England : 1990)
|January 12, 2016
Summary
Harnessing CD137 (cluster of differentiation 137) co-stimulatory receptor targeting shows promise for effective immunotherapies by modulating the tumor microenvironment (TME) and immune responses.
Area of Science:
- Immunology
- Oncology
- Pharmacology
Background:
- Effective cancer immunotherapies depend on understanding the tumor microenvironment (TME) and immune response interplay.
- Co-stimulatory receptor-targeting strategies are gaining clinical traction.
- CD137 (cluster of differentiation 137), a TNF receptor superfamily member, is a key target due to its role in immune cell modulation.
Purpose of the Study:
- To review CD137-targeted immunotherapeutics in clinical development.
- To highlight novel modalities like CD137 chimeric antigen receptors and bispecific antibodies.
- To discuss the impact of CD137 targeting on the TME and its implications for treatment efficacy.
Main Methods:
- Literature review of clinical CD137-targeted immunotherapeutics.
- Analysis of recent advances and novel therapeutic modalities.
- Examination of CD137's effect on the tumor microenvironment.
Main Results:
- Various CD137-targeted immunotherapeutics have advanced to clinical trials.
- Novel approaches including CARs and bispecific antibodies are emerging.
- CD137 targeting modulates the TME and immune cell activity.
Conclusions:
- CD137 is a promising target for cancer immunotherapy.
- Understanding TME modulation is crucial for predicting and enhancing CD137-mediated immunotherapy efficacy.
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