Related Experiment Video

Updated: Mar 27, 2026

Evaluating the Angiogenetic Properties of Ovarian Cancer Stem-Like Cells using the Three-Dimensional Co-Culture System, NICO-1
07:59

Evaluating the Angiogenetic Properties of Ovarian Cancer Stem-Like Cells using the Three-Dimensional Co-Culture System, NICO-1

Published on: December 5, 2020

3.1K

Targeting Stromal-Cancer Cell Crosstalk Networks in Ovarian Cancer Treatment

Tsz-Lun Yeung1, Cecilia S Leung2, Fuhai Li3

  • 1Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA. TYeung@mdanderson.org.

Biomolecules
|January 12, 2016
PubMed

Insights

Ovarian cancer progression is influenced by signaling crosstalk between cancer cells and stromal cells, particularly cancer-associated fibroblasts (CAFs). Targeting this crosstalk offers new therapeutic strategies for ovarian cancer treatment.

Area of Science:

  • Oncology
  • Cell Biology
  • Gynecologic Oncology

Background:

  • Ovarian cancer is a diverse and lethal gynecologic malignancy with poor survival rates.
  • Tumor tissue comprises cancer cells and stromal cells, with stromal involvement crucial in pathogenesis.
  • Cancer-associated fibroblasts (CAFs) are key stromal components supporting tumor progression.

Purpose of the Study:

  • To review signaling crosstalk between ovarian cancer cells and stromal cells, focusing on CAFs.
  • To evaluate the role of signaling crosstalk in ovarian cancer progression.
  • To discuss therapeutic strategies targeting tumor-promoting signaling crosstalk.

Main Methods:

  • Literature review of signaling pathways and crosstalk in ovarian cancer.
  • Analysis of the role of cancer-associated fibroblasts (CAFs) in tumor progression.
  • Identification of potential therapeutic targets within stroma-specific signaling pathways.

Main Results:

  • Stromal cells, especially CAFs, significantly influence ovarian cancer pathogenesis.
  • Signaling crosstalk between cancer cells and CAFs promotes tumor progression.
  • Stroma-specific pathways present opportunities for improved diagnosis and treatment.

Conclusions:

  • Targeting signaling crosstalk between ovarian cancer cells and CAFs is a promising therapeutic avenue.
  • Understanding stroma-cancer cell interactions is vital for developing effective ovarian cancer treatments.
  • Therapeutic strategies focused on tumor stroma can potentially improve patient outcomes.
Keywords:
cancer-associated fibroblastsovarian cancerstromal-tumor crosstalktumor microenvironment

More Related Videos

Murine Model for Non-invasive Imaging to Detect and Monitor Ovarian Cancer Recurrence08:55

Murine Model for Non-invasive Imaging to Detect and Monitor Ovarian Cancer Recurrence

Published on: November 2, 2014

12.9K
A Proximal Culture Method to Study Paracrine Signaling Between Cells08:17

A Proximal Culture Method to Study Paracrine Signaling Between Cells

Published on: August 28, 2018

10.2K

Related Concept Videos

The Tumor Microenvironment02:17

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
8.1K
Cancer Stem Cells and Tumor Maintenance02:40

Cancer Stem Cells and Tumor Maintenance

Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
6.3K
Cancer Stem Cells and Tumor Maintenance02:40

Cancer Stem Cells and Tumor Maintenance

2.3K
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
5.1K
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

1.7K
Treatment Resistant Cancers02:56

Treatment Resistant Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
3.9K