Corneal Thickness Profile and Associations in Chinese Children Aged 7 to 15 Years Old
Yingyan Ma1,2, Xiaofeng Zhu2, Xiangui He1,3
1Shanghai Eye Hospital, Shanghai Eye Disease Prevention & Treatment Center, Shanghai, China.
Insights
Central corneal thickness (CCT) in Chinese children correlates with corneal curvature radius but not age or gender. Thicker corneas are linked to higher intraocular pressure (IOP).
Area of Science:
- Ophthalmology
- Biometry
- Corneal topography
Background:
- Corneal thickness (CT) is a crucial parameter in ophthalmology.
- Understanding factors influencing CT and its relationship with intraocular pressure (IOP) is vital for diagnosing and managing eye conditions.
Purpose of the Study:
- To map corneal thickness in Chinese children aged 7-15 years.
- To investigate the influence of age, gender, refraction, axial length, and corneal curvature radius (CCR) on CT.
- To analyze the relationship between central corneal thickness (CCT) and IOP.
Main Methods:
- Fourier-domain optical coherence tomography was used to measure CT maps.
- Multiple regression analyses were performed on data from 1228 eyes of 614 children.
- Noncontact tonometry measured IOP.
Main Results:
- Average CCT was approximately 532.8 μm.
- A 10 μm increase in CCT correlated with a 0.37 mm Hg increase in IOP.
- CT increased from the center to the periphery, with superior regions being thickest.
- CCT was associated with CCR (p=0.008) but not age, gender, axial length, or refraction.
- Para-central and peripheral CT were associated with younger age, male gender, and flatter corneas.
Conclusions:
- Corneal thickness distribution varies across the cornea in children.
- Central corneal thickness is a significant predictor of IOP.
- Corneal curvature radius is a key factor influencing CCT in this population.
Abstract:
Corneal thickness (CT) maps of the central (2-mm diameter), para-central (2 to 5-mm diameter), peripheral (5 to 6-mm diameter), and minimum (5-mm diameter) cornea were measured in normal Chinese school children aged 7 to 15 years old using Fourier-domain optical coherence tomography. Multiple regression analyses were performed to explore the effect of associated factors [age, gender, refraction, axial length and corneal curvature radius (CCR)] on CT and the relationship between central corneal thickness (CCT) and intraocular pressure (IOP). A total of 1228 eyes from 614 children were analyzed. The average CCT was 532.96 ± 28.33 μm for right eyes and 532.70 ±28.45 μm for left eyes. With a 10 μm increase in CCT, the IOP was elevated by 0.37 mm Hg, as measured by noncontact tonometry. The CT increased gradually from the center to the periphery. The superior and superior nasal regions had the thickest CTs, while the thinnest points were primarily located in the inferior temporal cornea. The CCT was associated with CCR (p = 0.008) but not with gender (p = 0.075), age (p = 0.286), axial length (p = 0.405), or refraction (p = 0.985). In the para-central region and the peripheral cornea, increased CT was associated with younger age, male gender, and a flatter cornea.
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