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Mobility-Selected Ion Trapping and Enrichment Using Structures for Lossless Ion Manipulations
Tsung-Chi Chen1, Yehia M Ibrahim1, Ian K Webb1
1Biological Sciences Division, Pacific Northwest National Laboratory , Richland, Washington 99352, United States.
Analytical Chemistry
|January 12, 2016
Summary
Structures for Lossless Ion Manipulations (SLIM) enhance ion mobility spectrometry-mass spectrometry (IMS-MS) by enabling ion trapping and accumulation. This method improves analytical sensitivity for low-abundance ions through effective ion separation and enrichment.
Area of Science:
- Analytical Chemistry
- Physical Chemistry
Background:
- Ion mobility spectrometry-mass spectrometry (IMS-MS) is crucial for ion manipulation, reactions, and enhancing sensitivity.
- Structures for Lossless Ion Manipulations (SLIM) provide advanced capabilities for complex ion manipulations.
Purpose of the Study:
- To demonstrate a SLIM-based module for ion separation, trapping, and accumulation.
- To optimize SLIM components for enhanced ion enrichment and analytical sensitivity.
Main Methods:
- Development of a SLIM module featuring a linear ion drift region, switch/tee, and trapping region.
- Operation and optimization of SLIM switch/tee and trapping functionalities.
- Demonstration of ion enrichment for low-abundance species.
Main Results:
- Successful isolation and accumulation of mobility-separated ions using the SLIM module.
- Optimization of SLIM switch/tee and trap operations.
- Linear increase in ion intensity with repeated trapping/accumulation events, confirming sensitivity enhancement.
Conclusions:
- The SLIM-based module effectively separates and traps ions, enabling enrichment of low-abundance species.
- SLIM technology significantly enhances the sensitivity of IMS-MS analyses.
- This approach offers potential for complex ion manipulation sequences and improved analytical performance.
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