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Related Experiment Videos

Adrenal gland: chemically induced structural and functional changes in the cortex.

S Szabo1, I T Lippe

  • 1Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts 02115.

Toxicologic Pathology
|January 1, 1989
PubMed
Summary

Certain chemicals can cause hemorrhagic necrosis in the adrenal cortex. A structure-activity correlation predicts this toxicity in alkyl chemicals, detailing a six-step pathogenesis involving vascular damage and hemorrhage.

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Area of Science:

  • Toxicology
  • Endocrinology
  • Pathology

Background:

  • The adrenal cortex is susceptible to numerous exogenous chemicals.
  • Chemical induction of adrenal necrosis was previously discovered serendipitously.
  • A structure-activity correlation for adrenocorticolytic alkyl chemicals has been identified.

Purpose of the Study:

  • To elucidate the pathogenetic sequence of chemically induced hemorrhagic adrenocortical necrosis.
  • To identify structure-activity relationships predicting adrenocorticolytic properties.
  • To investigate the role of specific chemicals like acrylonitrile in this process.

Main Methods:

  • Electron microscopy
  • Histochemical studies
  • Biochemical analyses

Related Experiment Videos

  • Structure-activity relationship analysis

    • Main Results:

    • A six-step pathogenetic sequence for chemically induced adrenocortical necrosis was proposed.
    • Key events include glutathione depletion, endothelial damage, embolization, vascular wall destruction, and hemorrhage.
    • Acrylonitrile, cysteamine, and pyrazole were studied, with acrylonitrile investigated in detail.

    Conclusions:

    • A detailed pathogenetic sequence for chemical-induced adrenal necrosis has been established.
    • The findings provide a predictive model for adrenocorticolytic alkyl chemicals.
    • Understanding this mechanism is crucial for toxicology and adrenal gland research.