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Alzheimer's Model Develops Early ADHD Syndrome
Qiang Zhang1, Guiping Du1, V John2
1Buck Institute for Research on Aging, 8001 Redwood Blvd., Novato, CA 94945, USA.
Abstract:
We describe the first invertebrate model of attention deficit hyperactivity disorder (ADHD) that reproduces its major features, including hyperactivity, male predominance, marked exacerbation by simple carbohydrates, reversible response to dextroamphetamine, and a "paradoxical response" to stimulants. This model may offer new insight into ADHD pathogenesis and treatment. Furthermore, these findings are of particular interest in light of the recent epidemiological evidence showing that patients with dementia have a high frequency of antecedent ADHD symptoms.
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