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Author Spotlight: Optimizing Scorpion Venom Extraction for Antivenom Production

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Published on: October 6, 2023

Nanofibrous Snake Venom Hemostat.

Vivek A Kumar¹, Navindee C Wickremasinghe¹, Siyu Shi¹

¹Departments of Chemistry and Bioengineering, Rice University, 6100 Main Street, Houston, Texas 77030, United States.

ACS Biomaterials Science & Engineering

|January 12, 2016

Summary

A novel peptide hydrogel loaded with Batroxobin (SB50) effectively stops bleeding, even in patients on anticoagulant therapy like heparin. This innovative hemostatic agent offers rapid control of surgical hemorrhage.

Keywords:

hemostasis multidomain peptide self-assembly supramolecular chemistry

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Published on: November 3, 2014

Area of Science:

Biomaterials Science
Hemostasis Research
Nanotechnology

Background:

Perioperative bleeding poses significant risks, especially for patients on anticoagulant therapy.
Heparin therapy diminishes blood clotting potential, increasing hemorrhage risk.
Effective hemostatic agents are crucial for minimizing surgical complications and mortality.

Purpose of the Study:

To develop and evaluate a novel self-assembling peptide hydrogel (SLac) loaded with Batroxobin (SB50) as a rapid hemostatic agent.
To assess the efficacy of SB50 in controlling bleeding, particularly in the presence of heparin.
To compare the performance of SB50 against existing hemostatic agents.

Main Methods:

Fabrication of a self-assembling nanofibrous peptide hydrogel (SLac).
Loading of SLac with Batroxobin to create SB50 (50 μg/mL).
In vitro evaluation of clotting in fibrin and whole blood.
In vivo assessment of SB50 in a rat lateral liver incision model, including heparin-treated subjects.

Main Results:

SB50 demonstrated rapid hemostasis within 20 seconds in both normal and heparin-treated rats.
The Batroxobin-loaded hydrogel conformed to the wound site, providing a physical barrier and enhancing clotting.
SB50 outperformed standard (Gelfoam) and investigational (Puramatrix) hemostats in achieving rapid liver incision hemostasis.

Conclusions:

The Batroxobin-loaded peptide hydrogel (SB50) provides a facile and effective method for surgical hemostasis.
SB50 is highly effective even in the presence of anticoagulant therapies like heparin.
This injectable hydrogel represents a promising advancement in managing surgical bleeding.