[Antidepressants do prevent suicide, at least pending something better...]

Area of Science:

• Public Health
• Neuroscience
• Psychiatry

Context:

• Suicide represents a significant global public health issue, causing approximately 1.5 million deaths annually.
• France holds the 7th position in the EU for suicide rates.
• A substantial proportion of completed suicides involve patients with depression, many of whom are inadequately treated.

Purpose:

• To review the existing data and ongoing controversy surrounding the potential suicidogenic effects of antidepressants.
• To highlight the life-saving potential of antidepressants when effectively used in depression treatment.
• To emphasize the need for improved understanding of suicidal behavior disorder pathophysiology.

Summary:

• Depression is a primary risk factor for suicide, suggesting improved treatment could lower mortality rates.
• Despite their efficacy in treating depression, antidepressants have been subject to debate regarding their association with increased suicide risk.
• This review synthesizes evidence on antidepressants and suicide, addressing the controversy and underscoring their therapeutic value.

Impact:

• Enhanced understanding of suicidal behavior disorder pathophysiology can guide the development of novel therapeutic targets.
• Effective treatment of depression, including appropriate use of antidepressants, is critical for reducing suicide mortality.
• Further research into the mechanisms underlying suicidal behavior is essential for creating innovative suicide prevention strategies.