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ANRIL: a pivotal tumor suppressor long non-coding RNA in human cancers

Zheng Li1, Xin Yu2, Jianxiong Shen3

  • 1Department of Orthopedic Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100730, China.

Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine
|January 13, 2016
PubMed

Insights

Long non-coding RNAs (lncRNAs) are key regulators in cell development and cancer. LncRNA ANRIL acts as an oncogene in various cancers, impacting proliferation and migration, and may serve as a diagnostic biomarker.

Area of Science:

  • Molecular Biology
  • Genetics
  • Oncology

Background:

  • Long non-coding RNAs (lncRNAs) are critical regulators in biological processes.
  • Aberrant lncRNA expression is implicated in tumorigenesis, with lncRNAs acting as oncogenes or tumor suppressors.
  • LncRNA ANRIL is frequently dysregulated in multiple human cancers.

Purpose of the Study:

  • To review the current understanding of lncRNA ANRIL expression and its functional roles in various cancer types.
  • To highlight ANRIL's oncogenic activity and potential as a diagnostic and prognostic biomarker.

Main Methods:

  • Literature review of studies investigating lncRNA ANRIL in cancer.
  • Analysis of ANRIL's expression patterns across different tumor types.
  • Summary of experimental evidence on ANRIL's functional impact on cancer cell behavior.

Main Results:

  • LncRNA ANRIL is overexpressed in gastric cancer, lung cancer, hepatocellular carcinoma, and esophageal squamous cell carcinoma.
  • Inhibition of ANRIL demonstrates suppression of cancer cell proliferation, migration, and invasion.
  • ANRIL shows potential as a biomarker for cancer diagnosis and prognosis.

Conclusions:

  • LncRNA ANRIL is a significant oncogene across a spectrum of human cancers.
  • Targeting ANRIL may offer therapeutic strategies for cancer treatment.
  • ANRIL warrants further investigation as a valuable biomarker in oncology.
Keywords:
ANRILCancerLong non-coding RNAslncRNAs

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