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Published on: April 12, 2024
Genetic polymorphisms in MMP 2, 3 and 9 genes and the susceptibility of osteosarcoma in a Chinese Han population
Yan Cui1, Jia-Jun Zhu1, Cheng-Bin Ma1
1a Department of Orthopaedics , The Fourth Affiliated Hospital of China Medical University , Shenyang , Liaoning Province , China.
Background:
There are no data about the role of MMPs polymorphism in development of osteosarcoma.
Patients And Methods:
Two-hundred fifty-one patients with osteosarcoma and 251 healthy controls were included to investigate the association between the MMP2, 3, 9 polymorphisms and the risk of osteosarcoma.
Results:
Compared with the MMP2 SNP rs243865 homozygote CC, The heterozygous CT genotype was associated with significantly increased risk for osteosarcoma (OR = 1.86, 95% CI = 1.18-4.22, p = 0.014); the TT genotype was associated with increased risk for osteosarcoma (OR = 1.92, 95% CI = 1.21-3.52, p = 0.028). However, the genotype and allele frequencies of MMP3 rs3025058 and MMP9 rs3918242 polymorphisms were not significantly different.
Conclusion:
MMP2 rs243865 genotype was associated with increased risk for development of osteosarcoma in Chinese Han population.
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