Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Mitochondrial Membranes01:45

Mitochondrial Membranes

17.8K
A single mitochondrion is a bean-shaped organelle enclosed by a double-membrane system. The outer membrane of mitochondria is smooth and contains many porins - the integral membrane transporters. Porins enable free diffusion of ions and small uncharged molecules through the outer mitochondrial membrane but limit the transport of molecules larger than 5000 Daltons. Further, the outer mitochondrial membrane forms a unique structure called membrane contact sites with other subcellular organelles,...
17.8K
Mitochondrial Membranes01:45

Mitochondrial Membranes

2.3K
2.3K
Regulation of Metabolism01:19

Regulation of Metabolism

12.3K
Cellular needs and conditions vary from cell to cell and change within individual cells over time. For example, the required enzymes and energetic demands of stomach cells are different from those of fat storage cells, skin cells, blood cells, and nerve cells. Furthermore, a digestive cell works much harder to process and break down nutrients during the time that closely follows a meal compared with many hours after a meal. As these cellular demands and conditions vary, so do the amounts and...
12.3K
The Inner Mitochondrial Membrane01:28

The Inner Mitochondrial Membrane

5.0K
The inner mitochondrial membrane is the primary site of ATP synthesis. The inner membrane domain that forms a smooth layer adjacent to the outer membrane is called the inner boundary membrane. This domain contains membrane transporters that drive metabolites in and out of the mitochondria.  In contrast, the inner membrane network that invaginates into the matrix space is called the cristae membrane. This domain accounts for principle mitochondrial function as it accommodates the protein...
5.0K
Mitochondria01:37

Mitochondria

21.3K
Mitochondria are eukaryotic cellular organelles that are known to produce energy through a process called oxidative phosphorylation. Besides their primary function, mitochondria are involved in various cellular processes, including cell growth, differentiation, signaling, metabolism, and senescence. Age-related changes cause a decline in mitochondrial quality and integrity due to increased mitochondrial mutations and oxidative damage. Thus, aging can severely impact mitochondrial functions,...
21.3K
Introduction to Metabolism01:30

Introduction to Metabolism

3.5K
Metabolism encompasses all biochemical reactions in a living organism, facilitating both the breakdown and synthesis of biomolecules. These metabolic processes are categorized into catabolic and anabolic pathways, which operate in a coordinated manner to ensure energy balance and cellular function.Catabolic Pathways and Energy ReleaseCatabolic pathways involve the breakdown of complex macromolecules such as carbohydrates, lipids, and proteins into smaller structures like monosaccharides, fatty...
3.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Fluid-induced acid-base variations in postoperative critically ill patients: physiological determinants and renal response.

Frontiers in medicine·2026
Same author

Clinical outcome 24 months after cervical disc arthroplasty with a new articulating and viscoelastic disc prosthesis.

Journal of spine surgery (Hong Kong)·2026
Same author

Vitamin C appears harmful in patients after out-of-hospital cardiac arrest treated in the intensive care unit.

Intensive care medicine·2026
Same author

Limiting neurodegeneration in ALS: A phosphatase paves the way.

Neuron·2026
Same author

Mitochondria limit coenzyme Q export under cholesterol biosynthetic stress.

The Journal of cell biology·2026
Same author

Author Correction: Myocardial disarray drives metabolic inefficiency in human cardiomyocytes.

Communications biology·2026

Related Experiment Video

Updated: Mar 27, 2026

Assessment of Mitochondrial Fission/Fusion Dynamics in Kidney Proximal Tubular Cells
06:14

Assessment of Mitochondrial Fission/Fusion Dynamics in Kidney Proximal Tubular Cells

Published on: November 14, 2025

755

Mitochondrial Dynamics and Metabolic Regulation.

Timothy Wai1, Thomas Langer2

  • 1Institute for Genetics, University of Cologne, Cologne, Germany; Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany.

Trends in Endocrinology and Metabolism: TEM
|January 13, 2016
PubMed
Summary

Mitochondrial morphology, shaped by fusion and fission, impacts cell metabolism. Disruptions in mitochondrial shape are linked to metabolic dysfunction and disease, highlighting its critical role.

Keywords:
fissionfusionmetabolismmitochondriamitochondrial dynamics

More Related Videos

Understanding the Changes in Mitochondrial Morphology through Dynamic and Three-dimensional Fluorescence Micrographs
08:15

Understanding the Changes in Mitochondrial Morphology through Dynamic and Three-dimensional Fluorescence Micrographs

Published on: August 15, 2025

1.3K
Studying Mitochondrial Structure and Function in Drosophila Ovaries
09:53

Studying Mitochondrial Structure and Function in Drosophila Ovaries

Published on: January 4, 2017

25.0K

Related Experiment Videos

Last Updated: Mar 27, 2026

Assessment of Mitochondrial Fission/Fusion Dynamics in Kidney Proximal Tubular Cells
06:14

Assessment of Mitochondrial Fission/Fusion Dynamics in Kidney Proximal Tubular Cells

Published on: November 14, 2025

755
Understanding the Changes in Mitochondrial Morphology through Dynamic and Three-dimensional Fluorescence Micrographs
08:15

Understanding the Changes in Mitochondrial Morphology through Dynamic and Three-dimensional Fluorescence Micrographs

Published on: August 15, 2025

1.3K
Studying Mitochondrial Structure and Function in Drosophila Ovaries
09:53

Studying Mitochondrial Structure and Function in Drosophila Ovaries

Published on: January 4, 2017

25.0K

Area of Science:

  • Cell Biology
  • Metabolic Biochemistry
  • Mitochondrial Dynamics

Background:

  • Mitochondrial morphology varies across cell types and responds to metabolic cues and external insults.
  • Mitochondrial shape is dynamically regulated by fusion and fission of outer and inner membranes (OM and IM).
  • Altered mitochondrial morphology, such as fragmentation or hyperfusion, is associated with metabolic dysfunction and disease.

Purpose of the Study:

  • To review the relationship between metabolic alterations and changes in mitochondrial morphology.
  • To explore how disruptions in mitochondrial morphology impact cellular and organismal metabolism.

Main Methods:

  • Literature review of studies investigating mitochondrial morphology and metabolism.
  • Analysis of the roles of mitochondrial fusion and fission in response to metabolic changes.
  • Examination of the consequences of altered mitochondrial morphology on cellular functions.

Main Results:

  • Metabolic alterations significantly influence mitochondrial morphology.
  • Mitochondrial fragmentation (unopposed fission) is linked to metabolic dysfunction and disease.
  • Mitochondrial hyperfusion (unopposed fusion) can counteract metabolic insults and preserve cellular integrity.

Conclusions:

  • Mitochondrial morphology is a critical determinant of cellular and organismal metabolism.
  • Understanding the interplay between metabolism and mitochondrial dynamics is crucial for addressing metabolic diseases.
  • Targeting mitochondrial morphology may offer therapeutic strategies for metabolic disorders.