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The physiological function of a cell and cellular communication are outcomes of a range of extrinsic signals, intracellular signaling pathways, and cellular responses. No two cell types express the same repertoire of signaling components. Receptors are highly selective for their cognate ligands, but once activated, they can alter multiple cellular processes such as DNA transcription, protein synthesis, and metabolic activity. 
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Agonists can bind with and activate receptors, resulting in the formation of drug-receptor complexes. Once formed, these complexes catalyze many biochemical processes at the cellular level and subsequently induce a pharmacologic response. The degree of response is directly proportional to the fraction of activated receptors, which in turn, depends on the concentration of the drug at the receptor site as well as the sensitivity of the receptor. An increase in the administered dose contributes to...
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Modeling Verbal Behavior Deficits with the Stimulus Control Ratio Equation, SCoRE
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Response

Francesco Sclafani1, David Cunningham2, Clare Peckitt2

  • 1The Royal Marsden NHS Foundation Trust, London and Surrey, United Kingdom (FS, DC, CP, DW). francesco.sclafani@rmh.nhs.uk.

Journal of the National Cancer Institute
|January 13, 2016
PubMed
Summary

No abstract available in PubMed .

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