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Updated: Mar 27, 2026
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Whole-Kidney Three-Dimensional Staining with CUBIC
Published on: July 18, 2022
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Kidney
A Hart1, J M Smith2,3, M A Skeans3
1Department of Medicine, Hennepin County Medical Center, University of Minnesota, Minneapolis, MN.
Summary
Kidney transplant offers better survival and quality of life than dialysis for end-stage kidney disease patients. Waiting lists and times grew in 2014, but graft survival improved post-transplant.
Area of Science:
- Nephrology
- Transplantation Medicine
- Public Health
Background:
- Kidney transplantation significantly improves survival, cost-effectiveness, and quality of life compared to dialysis for end-stage kidney disease (ESKD).
- The number of patients on the kidney transplant waiting list, including adults and pediatrics, has steadily increased, reaching nearly 100,000 adults and 1500 pediatric candidates by the end of 2014.
- Consequently, waiting times for transplantation have lengthened, and the number of candidates removed from the list due to mortality or worsening health has also risen.
Purpose of the Study:
- To analyze trends in kidney transplant waiting lists, candidate demographics, and outcomes up to 2014.
- To evaluate the impact of deceased and living donor kidney transplants on graft survival in adult recipients.
- To establish a baseline for assessing future trends following the implementation of a new organ allocation system in late 2014.
Main Methods:
- Retrospective analysis of national kidney transplant waiting list data and recipient outcomes.
- Examination of trends in waiting list numbers, waiting times, and candidate removal reasons.
- Assessment of death-censored graft survival rates for adult recipients of both living and deceased donor kidney transplants over the past decade.
Main Results:
- The kidney transplant waiting list continued to grow in 2014, with increasing waiting times and candidate removals due to death or poor health.
- Death-censored graft survival rates have shown improvement for both living and deceased donor kidney transplants in adult recipients over the last ten years.
- Most observed trends from the preceding five years persisted through 2014, prior to the new allocation system's implementation.
Conclusions:
- Despite improved graft survival, the growing demand for kidney transplants outpaces supply, leading to longer waiting times and increased mortality among candidates.
- The introduction of a new organ allocation system in late 2014 presents a critical juncture for future analysis of transplant trends and outcomes.
- Continued monitoring and strategic adjustments to organ allocation are essential to address the persistent challenges in kidney transplantation.
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