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Updated: Mar 27, 2026
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Pharmacologic Induction of Epidermal Melanin and Protection Against Sunburn in a Humanized Mouse Model
Published on: September 7, 2013
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Melatonin-based pickering emulsion for skin's photoprotection.
Joana Marto1, Andreia Ascenso1, Lídia M Gonçalves1
1a Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, University of Lisbon , Portugal and.
Drug Delivery
|January 13, 2016
Summary
This study developed an innovative melatonin sunscreen Pickering emulsion offering significant protection against UV-induced skin damage. The formulation provides powerful antioxidant and anti-apoptotic effects, ensuring high SPF protection against UVA and UVB rays.
Area of Science:
- Dermatology
- Cosmetic Science
- Materials Science
Background:
- Melatonin exhibits antioxidant properties beneficial for photocarcinogenesis protection.
- Previous research indicates melatonin's potential in mitigating UV-induced skin damage.
Purpose of the Study:
- To create an innovative sunscreen using Pickering emulsions stabilized by physical UV filters, modified starch, and natural oils.
- To incorporate melatonin as a key ingredient for enhanced prevention of UV-induced skin damage.
Main Methods:
- Melatonin was integrated into Pickering emulsions for characterization via physicochemical, in vitro, and in vivo tests.
- In vitro studies assessed melatonin's protective effects against UV-induced HaCaT cell damage.
- In vivo safety and biological properties, including patch testing and water resistance, were evaluated.
Main Results:
- The melatonin sunscreen Pickering emulsion demonstrated significant protection against UVB-induced damage in HaCaT cells, including apoptosis inhibition.
- Formulations containing zinc oxide, titanium dioxide, green coffee oil, and starch achieved a high Sun Protection Factor (SPF 50+) for both UVA and UVB.
- The emulsion exhibited excellent physical and chemical stability.
Conclusions:
- The developed melatonin sunscreen Pickering emulsion offers substantial protection against UV-induced skin damage.
- The synergistic combination of melatonin, solid particles, and green coffee oil results in a stable and effective sunscreen.
- This innovative formulation provides meaningful synergistic protection against oxidative stress.
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