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Host receptors for bacteriophage adsorption.

Juliano Bertozzi Silva1, Zachary Storms1, Dominic Sauvageau2

  • 1Department of Chemical and Materials Engineering, University of Alberta, 12th Floor, Donadeo Innovation Centre for Engineering, 9211-116 Street NW, Edmonton, AB T6G 1H9, Canada.

FEMS Microbiology Letters
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Summary

Bacteriophage (phage) adsorption to host cells is essential for infection. This review surveys phage receptors and interactions, aiding phage ecology and technology development with the new Phage Receptor Database (PhReD).

Keywords:
bacterial phage resistancebacteriophage adsorptionhost receptorsphage attachment

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Area of Science:

  • Microbiology
  • Virology
  • Biotechnology

Background:

  • Bacteriophage (phage) adsorption to host cells is a critical initial step for infection.
  • Understanding phage-host interactions is vital for phage ecology and therapeutic applications.
  • Phage receptors play a key role in the specific recognition and attachment to host cells.

Purpose of the Study:

  • To review the known phage receptors involved in host cell recognition and adsorption.
  • To elucidate the mechanisms and factors influencing phage attachment to host cells.
  • To introduce the Phage Receptor Database (PhReD) as a resource for phage-host interaction research.

Main Methods:

  • Literature review of scientific publications on bacteriophage-host interactions.
  • Compilation and curation of data on identified phage receptors and their corresponding phages.
  • Development and establishment of the open-access Phage Receptor Database (PhReD).

Main Results:

  • Detailed survey of various phage receptors (e.g., proteins, polysaccharides) and their binding mechanisms.
  • Identification of key factors influencing phage adsorption efficiency and specificity.
  • Successful establishment of the Phage Receptor Database (PhReD) as a centralized information repository.

Conclusions:

  • Phage adsorption mechanisms are diverse and receptor-dependent, significantly impacting phage-host dynamics.
  • A comprehensive understanding of phage receptors is crucial for advancing phage-based technologies.
  • The Phage Receptor Database (PhReD) will facilitate future research into phage ecology and applications.