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A stereospecific solid-phase screening assay for colonies expressing both (R)- and (S)-selective ω-aminotransferases
Simon C Willies1, James L Galman1, Iustina Slabu1
1School of Chemistry, University of Manchester, Manchester Institute of Biotechnology, 131 Princess Street, Manchester M1 7DN, UK.
Abstract:
A novel solid-phase screening assay was developed for colonies expressing both (R)- and (S)-selective ω-aminotransferases. This high-throughput assay can be used to screen rapidly large variant libraries with enhanced substrate selectivity and enantioselectivities.
