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Published on: June 15, 2020
Left ventricular function assessment in cirrhosis: Current methods and future directions
Francisco Sampaio1, Joana Pimenta1
1Francisco Sampaio, Cardiology Department, Centro Hospitalar de Gaia/Espinho, 4430-502 Vila Nova de Gaia, Portugal.
Insights
Cirrhotic cardiomyopathy is cardiac dysfunction in cirrhosis. This review covers non-invasive imaging for assessing heart function in these patients, highlighting current and future diagnostic tools.
Area of Science:
- Cardiology
- Hepatology
- Medical Imaging
Background:
- Cirrhotic cardiomyopathy (CC) is characterized by cardiac dysfunction in cirrhosis patients.
- It involves impaired contractile responsiveness and diastolic relaxation, with electrophysiological abnormalities.
- Diagnosis is challenging due to hyperdynamic circulation, limiting conventional methods.
Purpose of the Study:
- To review current non-invasive imaging technologies for assessing left ventricular systolic and diastolic function in cirrhosis.
- To explore emerging imaging modalities with future clinical potential for CC diagnosis and management.
Main Methods:
- Literature review of non-invasive cardiovascular imaging modalities.
- Focus on echocardiography, cardiac MRI, and CT.
- Discussion of advanced techniques like strain imaging and cardiac biomarkers.
Main Results:
- Echocardiography is widely used but has limitations in cirrhotic patients.
- Newer modalities offer improved accuracy in detecting subtle cardiac dysfunction.
- Advanced imaging can better characterize CC, aiding clinical decisions.
Conclusions:
- Non-invasive imaging is crucial for diagnosing cirrhotic cardiomyopathy.
- Evolving technologies promise more precise assessment of cardiac function in cirrhosis.
- Accurate diagnosis influences patient management and prognosis.
Abstract:
Cirrhotic cardiomyopathy has been defined as a chronic cardiac dysfunction in patients with cirrhosis characterized by impaired contractile responsiveness to stress and/or altered diastolic relaxation with electrophysiological abnormalities in the absence of other known cardiac disease. Non-invasive cardiovascular imaging modalities play a major role in unmasking systolic and diastolic dysfunction in patients with cirrhosis. Echocardiography has been the most commonly used modality for assessing myocardial function in these patients. Conventional echocardiographic indices rely on several assumptions that may limit their applicability in patients with a hyperdynamic circulation. Newer imaging modalities may contribute to a more accurate diagnosis of cardiovascular abnormalities in cirrhotic patients, thereby influencing clinical management. We aimed to review the different non-invasive imaging technologies currently used for assessing left ventricular systolic and diastolic function in cirrhosis, as well as to describe new imaging modalities with potential clinical applicability in the near future.
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