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Association between hepatitis B and metabolic syndrome: Current state of the art

Peter Jarcuska1, Sylvia Drazilova1, Jan Fedacko1

  • 1Peter Jarcuska, Jan Fedacko, Daniel Pella, Martin Janicko, 1 Department of Internal Medicine, University Hospital and Pavol Jozef Šafárik University in Kosice, 04001 Košice, Slovakia.

World Journal of Gastroenterology
|January 13, 2016
PubMed

Insights

Metabolic syndrome (MetS) worsens outcomes for chronic hepatitis B (CHB) patients, increasing risks of liver cirrhosis and cancer. Lifestyle and medical interventions are crucial for managing these risks.

Area of Science:

  • Hepatology
  • Metabolic Diseases
  • Public Health

Background:

  • Chronic hepatitis B (CHB) is a significant global health concern, elevating the risk of liver cirrhosis and hepatocellular carcinoma.
  • Metabolic syndrome (MetS) is prevalent in developed nations, linked to cardiovascular disease, diabetes, and cancer.

Purpose of the Study:

  • To systematically review existing literature on the relationship between Metabolic Syndrome and Chronic Hepatitis B infection.
  • To investigate the impact of MetS on the progression of liver disease in CHB patients.

Main Methods:

  • Systematic literature review of published studies.
  • Analysis of correlations between CHB, MetS, and related conditions like non-alcoholic fatty liver disease and dyslipidemia.

Main Results:

  • Variable correlations observed between CHB and MetS, non-alcoholic fatty liver disease, and dyslipidemia.
  • No current evidence links CHB with diabetes mellitus or atherosclerosis.
  • MetS presence in CHB patients elevates the risk of fibrosis, cirrhosis, and hepatocellular carcinoma.

Conclusions:

  • Metabolic syndrome exacerbates liver disease progression and cancer risk in Chronic Hepatitis B patients.
  • Lifestyle modifications and pharmacological treatments are essential to mitigate complications associated with CHB and MetS.

Keywords:
CirrhosisFibrosisHepatitis BHepatocellular carcinomaMetabolic syndromeNonalcoholic fatty liver disease

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