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Anticoagulant treatment for subsegmental pulmonary embolism
Hugo H B Yoo1, Thais H A T Queluz, Regina El Dib
1Department of Internal Medicine, Botucatu Medical School, UNESP - Univ Estadual Paulista, Distrito de Rubiao Junior, s/n, Campus de Botucatu, Botucatu, Sao Paulo, Brazil, 18618-970.
The Cochrane Database of Systematic Reviews
|January 13, 2016
Summary
Current research lacks randomized controlled trials on anticoagulation for subsegmental pulmonary embolism (SSPE). More studies are needed to determine effective and safe treatments for SSPE and incidental SSPE.
Area of Science:
- Cardiology
- Pulmonology
- Radiology
Background:
- Acute pulmonary embolism (PE) is a significant cause of cardiovascular mortality.
- Advances in CT pulmonary angiography (CTPA) increase diagnosis of peripheral PEs like isolated subsegmental PE (SSPE).
- The clinical significance and optimal treatment for SSPE remain unclear, with potential for unnecessary anticoagulant risks.
Purpose of the Study:
- To evaluate the effectiveness and safety of anticoagulation versus no intervention for patients with isolated or incidental SSPE.
Main Methods:
- A systematic search of multiple databases (Cochrane Vascular, CENTRAL, MEDLINE, EMBASE, LILACS) was conducted.
- Included randomized controlled trials comparing anticoagulation therapy against no intervention for SSPE.
- Data extraction and quality assessment were planned by two independent reviewers.
Main Results:
- No randomized controlled trials met the inclusion criteria for this review.
- There is a lack of empirical evidence regarding the treatment of SSPE.
Conclusions:
- No definitive conclusions can be drawn regarding anticoagulation for SSPE due to the absence of RCT evidence.
- Further well-designed research is essential to guide clinical practice for SSPE management.
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