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Related Experiment Video

Updated: Mar 27, 2026

Author Spotlight: Advancing Prostate Cancer Research Through Improved Tissue Sampling and Biobanking

Author Spotlight: Advancing Prostate Cancer Research Through Improved Tissue Sampling and Biobanking

Published on: November 17, 2023

Prostate Cancer Grading: A Decade After the 2005 Modified Gleason Grading System.

Oleksandr N Kryvenko¹, Jonathan I Epstein

¹From the Department of Pathology and Laboratory Medicine, Department of Urology, and Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, Florida (Dr Kryvenko); and the Departments of Pathology, Urology, and Oncology, The Johns Hopkins Medical Institutions, Baltimore, Maryland (Dr Epstein).

Archives of Pathology & Laboratory Medicine

|January 13, 2016

Summary

This summary is machine-generated.

The Gleason grading system for prostate cancer has evolved since 1966. A new Grade Group system (1-5) has been developed and validated to improve prostate cancer grading accuracy.

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Area of Science:

Uropathology
Oncologic Histology

Background:

The original Gleason grading system, established in 1966, has limitations due to evolving diagnostic practices and the identification of new prostate cancer variants.
Patterns 1 and 2 are rarely diagnosed, and the original system did not account for reporting multiple biopsy cores or separate tumor nodules on radical prostatectomy.

Purpose of the Study:

To describe updates to prostate cancer grading.
To introduce and discuss the new Grade Group grading system (1-5).

Main Methods:

Review of historical changes in prostate cancer grading practices.
Description of the development and validation of the new Grade Group system.

Main Results:

The Gleason system has undergone revisions by the International Society of Urological Pathology in 2005 and 2014.
A new Grade Group system (1-5) was developed at Johns Hopkins and validated in multi-institutional studies.

Conclusions:

The new Grade Group system offers an updated approach to prostate cancer grading.
This system has been accepted by pathologists and clinicians, aiming to enhance diagnostic consistency and patient management.