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Fragmentation of synthetic cannabinoids with an isopropyl group or a tert-butyl group ionized by electron impact and
Shigeki Akamatsu1, Masashi Yoshida1
1Hyogo Prefectural Institute of Public Health and Consumer Sciences, 2-1-29, Arata-cho, Hyogo-ku, Kobe, 652-0032, Japan.
Abstract:
This study described a fragmentation pattern of 21 synthetic cannabinoids with an isopropyl group or a tert-butyl group by electron impact ionization quadrupole mass spectrometry and electrospray ionization time-of-flight mass spectrometry in the positive mode. The compounds were categorized into four types according to substituted group such as a terminal amide and ester. The characteristic fragment ion in each group was obtained. The main common fragment ions for the two ionizations were formed by C-N cleavage of the amide group adjacent to the N-hetero rings. Additionally, the fragment ions indicated the difference in the basic structure as well as substituted group, which are useful for estimating the chemical structures of unknown compounds. Copyright © 2015 John Wiley & Sons, Ltd.
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