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Updated: Aug 10, 2026

Application and Methodology of the Non-destructive 19F Time-domain NMR Technique to Measure the Content in Fluorine-containing Drug Products
Published on: August 22, 2017
[Bioavailability of fluorides from various salts and from various dietary components]
Abstract:
In six male subjects fluoride bio-availability after oral application of NaF and MgF2 was examined and the influence of food on fluoride absorption was studied by recording fluoride level in plasma and parotid saliva for 24 hours. In addition, fluoride profiles in the plasma of four beagle dogs after the intake of fluoride as NaF, MgF2 and CaF2 with and without addition of milk and dairy products were established. There were great differences in extent and speed of absorption among the different preparations some of which were demonstrated not to release fluoride at all. As was expected, absorption was quicker and more complete in patients with empty stomach than with simultaneous food intake. Milk and dairy products delay fluoride uptake without considerably reducing the overally amount of fluoride resorption.
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