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Progressing towards standard outcomes in gestational diabetes Cochrane reviews and randomised trials

Emily Bain1, Philippa Middleton1, Caroline A Crowther1,2

  • 1Australian Research Centre for Health of Women and Babies, Robinson Research Institute, Discipline of Obstetrics and Gynaecology, School of Medicine, The University of Adelaide, Adelaide, South Australia, Australia.

The Australian & New Zealand Journal of Obstetrics & Gynaecology
|January 13, 2016
PubMed

Insights

Standardized outcomes in gestational diabetes research increased after 2009. However, discrepancies persist between planned and reported outcomes, highlighting the need for a core outcome set to improve health research and patient well-being.

Area of Science:

  • Obstetrics and Gynecology
  • Clinical Trial Methodology
  • Health Services Research

Background:

  • Gestational diabetes research relies on diverse outcome measures, potentially leading to inconsistent evidence synthesis.
  • The WOMBAT (WOMen and Babies health and well-being: Action through Trials) initiative aimed to standardize outcomes in women's and children's health.
  • Assessing outcome reporting in gestational diabetes Cochrane reviews and protocols provides insight into research practices.

Purpose of the Study:

  • To survey outcomes in gestational diabetes Cochrane protocols and reviews before and after the WOMBAT initiative's development of 'standard outcomes'.
  • To evaluate changes in the frequency and consistency of outcome reporting over time.
  • To identify discrepancies between prespecified outcomes in reviews and those reported in randomized trials.

Main Methods:

  • Systematic survey of gestational diabetes Cochrane protocols and reviews.
  • Categorization and quantification of 'common' outcomes (prespecified in ≥50% of documents).
  • Comparative analysis of outcome reporting between two time periods (2001-2009 and 2010-2014).

Main Results:

  • An increase in 'common' outcomes was observed, rising from 27 in 2001-2009 to 46 in 2010-2014.
  • Significant discrepancies were identified between outcomes prespecified in systematic reviews and those actually reported by the included randomized trials.
  • The development of standard outcomes by WOMBAT correlated with an increase in common outcome reporting.

Conclusions:

  • While progress has been made in standardizing outcomes for gestational diabetes research, inconsistencies remain.
  • Addressing the identified discrepancies is crucial for reducing research waste and enhancing the reliability of evidence.
  • Developing a universally accepted core outcome set for gestational diabetes is essential for improving clinical practice and patient health outcomes.

Keywords:
clinical trialgestational diabetesoutcome assessmentresearch designsystematic review

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