Related Experiment Videos
The management of intransigent desquamative gingivitis with Dapsone
Annals of Dentistry
|January 1, 1989
Summary
Dapsone (diphenylsulphapyridine) therapy offered some benefit for desquamative gingivitis in 58% of patients with lichen planus or mucous membrane pemphigoid. Patients should be aware of potential side effects like nausea and headaches.
Area of Science:
- Oral Medicine
- Dermatology
- Pharmacology
Background:
- Desquamative gingivitis is a challenging oral condition.
- Lichen planus and benign mucous membrane pemphigoid are common causes.
- Intractable cases often require alternative treatments.
Purpose of the Study:
- To evaluate the efficacy of dapsone (diphenylsulphapyridine) in treating desquamative gingivitis.
- To assess patient outcomes and side effects of dapsone therapy.
Main Methods:
- A 3-month trial involving 15 patients with desquamative gingivitis.
- Treatment with dapsone (diphenylsulphapyridine).
- Clinical assessment via color transparencies and subjective patient reporting.
Main Results:
- 58% of patients experienced some therapeutic benefit.
- In lichen planus cases, 1/7 recovered fully, 3/7 improved.
- In mucous membrane pemphigoid cases, 3/5 improved, 2/5 showed no benefit.
- 3 patients withdrew due to side effects (headaches, nausea).
Conclusions:
- Dapsone therapy may be a useful option for refractory desquamative gingivitis.
- Potential benefits should be weighed against possible side effects.
- Patient counseling regarding side effects is recommended.