Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Contextualizing racial differences in baseline neuropsychological assessment of collegiate athletes.

Journal of the International Neuropsychological Society : JINS·2026
Same author

Symptom clusters and cognitive changes: predictors of recovery timelines following concussion in college athletes.

Journal of clinical and experimental neuropsychology·2026
Same author

Quality of Life, Self-Reported Cognitive Difficulties, and Performance-Based Cognitive Problems in Multiple Sclerosis: What's Sleep Got to Do With It?

Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists·2026
Same author

Clinical Manifestations.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2025
Same author

Get Your Brain in the Game: Using Machine Learning to Predict Recovery Timelines Following Sports-Related Concussion.

Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists·2025
Same author

Depressive Symptoms, Sleep Complaints, and Cognitive Performance: Examining the Mediating Role of Sleep in College Athletes.

Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists·2025
Same journal

The role of disadvantaged childhood conditions on cognitive function and disability in late life: findings from a Swedish longitudinal study.

Journal of clinical and experimental neuropsychology·2026
Same journal

Assessment of facial emotion recognition accuracy and reaction time in patients with social anxiety disorder diagnosed with performance-only specifier.

Journal of clinical and experimental neuropsychology·2026
Same journal

Stability and accuracy of specific learning disability diagnoses from childhood to young adulthood.

Journal of clinical and experimental neuropsychology·2026
Same journal

Performance validity test failure rates among neuropsychological outpatients clinically referred for persistent Long COVID cognitive symptoms following mild SARS-CoV-2 disease severity.

Journal of clinical and experimental neuropsychology·2026
Same journal

Correction.

Journal of clinical and experimental neuropsychology·2026
Same journal

A 50-year personal odyssey through the story of learning disabilities: from primary school to adult LD diagnoses.

Journal of clinical and experimental neuropsychology·2026
See all related articles

Related Experiment Video

Updated: Mar 27, 2026

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis
09:41

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis

Published on: July 19, 2019

12.2K

Structural brain indices and executive functioning in multiple sclerosis: A review.

Cristina A F Roman1, Peter A Arnett1

  • 1a Department of Psychology , The Pennsylvania State University, 372 Bruce V. Moore Building, University Park , PA , USA.

Journal of Clinical and Experimental Neuropsychology
|January 14, 2016
PubMed
Summary
This summary is machine-generated.

Multiple sclerosis (MS) causes brain damage, including white matter deterioration and atrophy. Neuroimaging reveals how this structural damage impacts cognitive functions like executive functioning in MS patients.

Keywords:
Multiple sclerosisatrophydiffusion tensor imagingexecutive functioninglesions

More Related Videos

Magnetic Resonance Imaging of Multiple Sclerosis at 7.0 Tesla
08:51

Magnetic Resonance Imaging of Multiple Sclerosis at 7.0 Tesla

Published on: February 19, 2021

10.1K
Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions
07:30

Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions

Published on: April 23, 2021

3.5K

Related Experiment Videos

Last Updated: Mar 27, 2026

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis
09:41

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis

Published on: July 19, 2019

12.2K
Magnetic Resonance Imaging of Multiple Sclerosis at 7.0 Tesla
08:51

Magnetic Resonance Imaging of Multiple Sclerosis at 7.0 Tesla

Published on: February 19, 2021

10.1K
Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions
07:30

Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions

Published on: April 23, 2021

3.5K

Area of Science:

  • Neurology
  • Neuroimaging
  • Cognitive Neuroscience

Background:

  • Multiple sclerosis (MS) is a neurological disorder causing white matter deterioration.
  • Brain atrophy and damage to normal appearing white matter (NAWM) and gray matter (NAGM) are consequences of MS.
  • MS presents in three primary clinical phenotypes: primary progressive (PPMS), relapsing remitting (RRMS), and secondary progressive (SPMS).

Purpose of the Study:

  • To provide an overview of executive functioning in MS.
  • To review structural damage in MS, including lesions, atrophy, and white matter damage.
  • To explore the relationship between structural brain damage and executive dysfunction in MS.

Main Methods:

  • Utilized conventional neuroimaging (e.g., T1-weighted imaging).
  • Employed nonconventional neuroimaging techniques (e.g., diffusion tensor imaging).
  • Reviewed existing literature on structural brain changes and cognitive function in MS.

Main Results:

  • Neuroimaging methods reveal structural integrity changes in the MS brain.
  • Structural damage manifests as sclerotic lesions, atrophy, and microstructural white matter damage.
  • These structural changes correlate with executive dysfunction in individuals with MS.

Conclusions:

  • Neuroimaging is crucial for understanding MS-related brain damage.
  • Structural brain alterations in MS are linked to impaired executive functioning.
  • Further research can elucidate the precise mechanisms connecting brain damage and cognitive deficits in MS.