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Updated: Mar 27, 2026

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Total synthesis and stereochemical revision of xiamenmycin A
Xiaozhen Jiao1, Yangyang Yao1, Beibei Yang1
1State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Beijing Key Laboratory of Active Substances Discovery and Drugability Evaluation, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100050, PR China. xp@imm.ac.cn.
Abstract:
The relative and absolute configurations of xiamenmycin A, a benzopyran compound isolated from Streptomyces xiamenensis 318 with a highly potent anti-fibrotic activity, have been characterized through the total synthesis. The key steps include the construction of the 3-chromanol moiety via Sharpless epoxidation followed by regio- and diastereo-selective cyclization and introduction of the threonine moiety at a later stage via Pd-catalysed aminocarbonylation in a one-pot procedure. The stereochemical assignment of natural xiamenmycin A has been accordingly revised to be 2R, 3S, 3'S, 4'R.
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