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SOX11 and HIG-2 are cross-regulated and affect growth in mantle cell lymphoma

Venera Kuci1,2, Lena Nordström1,2, Paolo Conrotto1,2

  • 1a Department of Immunotechnology , Lund University , Lund , Sweden ;

Leukemia & Lymphoma
|January 14, 2016
PubMed

Insights

SOX11 is crucial in mantle cell lymphoma (MCL). Researchers found SOX11 cross-regulates with HIG-2, a protein on the cell membrane that may be a target for new MCL therapies.

Area of Science:

  • Oncology
  • Molecular Biology
  • Cell Signaling

Background:

  • SOX11 is a key antigen in mantle cell lymphoma (MCL), typically absent in normal tissues.
  • Understanding SOX11-associated signaling networks is vital for developing targeted MCL therapies.

Purpose of the Study:

  • To identify genes and signaling pathways co-regulated with SOX11.
  • To investigate the potential of SOX11-related proteins as therapeutic targets in MCL.

Main Methods:

  • Utilized an inducible SOX11 knock-down system in MCL cells.
  • Performed gene expression analysis to identify co-regulated genes.
  • Confirmed protein-level co-regulation and cellular localization.

Main Results:

  • Identified 27 significantly co-regulated genes, including SETMAR, HIG-2, and CD24.
  • Confirmed protein-level co-regulation between SOX11, HIG-2, and CD24.
  • Demonstrated that HIG-2 knock-down decreases SOX11 levels and increases MCL cell proliferation, indicating cross-regulation.

Conclusions:

  • SOX11, HIG-2, and CD24 are co-regulated at the protein level in MCL.
  • HIG-2 is located on the plasma membrane of MCL cells and shows cross-regulation with SOX11.
  • HIG-2 represents a potential therapeutic target for mantle cell lymphoma.
Keywords:
HIG-2SETMAR and CD24SOX11

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